Arsenal have been drawn against FC Bayern Munich while Real Madrid will face defending champions Man City in the quarter-finals of the UEFA Champions League.
In other fixtures, Paris Saint-Germain meet Barcelona and Atletico Madrid will take on Borussia Dortmund in the other ties.
Pep Guardiola’s City will travel to the Spanish capital for the first leg on April 6 or 7, with the return in Manchester a week later.
City beat Madrid in the semi-finals last season on the way to winning the Champions League for the first time, following a 1-1 draw at the Santiago Bernabeu with a stunning 4-0 victory at home in the second leg.
Real came out on top when the teams met in the last four a year earlier, before going on to defeat Liverpool in the final.
The Spanish giants also won a semi-final clash between the teams in 2016, while City emerged victorious in the last 16 in 2020.
The draw threw up a set of mouthwatering ties with Arsenal being rewarded with a tie against German champions Bayern after beating Porto on penalties to qualify for the quarter-finals for the first time since 2010.
The Gunners will host the first leg at the Emirates Stadium, which will see former Tottenham Hotspur talisman Kane — who has so far scored 36 goals in his first season at Bayern — return to London.
There is the prospect of an all-English semi-final, with the winners of the tie between Arsenal and Bayern facing either City or Real in the last four.
PSG’s meeting with Barcelona will be the latest instalment in the rivalry between those sides, as the French club aim to win the Champions League for the first time in their final season before Kylian Mbappe departs when his contract expires in June.
Barcelona knocked PSG out in the quarter-finals in 2013 and 2015, before their spectacular victory in the last 16 in 2017, when they recovered from losing 4-0 away in the first leg with a 6-1 win in the return at the Camp Nou.
PSG avenged that defeat in the last 16 in 2021, when Mbappe scored a hat-trick in the away leg to help his side triumph 5-2 on aggregate.
Atletico will host Dortmund in the first leg of their quarter-final, with the winners of that taking on PSG or Barcelona in the last four.
This season’s Champions League final will take place at Wembley in London on June 1.
Quarter Final draw
Q4: Paris Saint Germain vs FC Barcelona
Q3: Real Madrid vs Manchester City
Q2: Atletico Madrid vs Borussia Dortmund
Q1: Arsenal vs Bayern Munich
Semi-final Pairing
Winners of Q2 vs Winners of Q4
Winners of Q1 vs Winners of Q3
This will be the last draw for the current format of the UEFA Champions League as a new format of 36 teams is set to commence in the 2024/25 season.
Dates of the Champions League quarter-final matches
The quarter-finals will be played on April 9 and 10 for the first leg, while the conclusions will come one week later, on the 16th and 17th of the same month.
